Inhalt - Experiments
Proteolytische Enzyme modulieren die Clq-Bindungskapazität
gebundener Immunkomplexe in vitro
Kunze R., Ransberger K., Stauder G., Gebauer F.
Amelioration of the progressive course of chronic renal failure
in subtotally nephrectomized rats by intraperitoneal enzyme therapy (deutsche version)
Sebekova K., Daemmrich J., Paczek L., Gaciong Z., Blazicek P., Spustova V., Heidland
A.
Contents - Experiments 
Transport of Proteolytic Enzymes Across Caco-2 Cell
Monolayers
Bock U., Kolac C., Borchard G., Koch K., Fuchs R., Streichhan P., Lehr C.-M.
Polyenzyme preparations interrupt the
autocrine loop of
TGFb production in melanoma cells by conversing a2Macroglobulin (a2M) in to the fast-form which binds TGF-beta irreversible
Desser, L., Herbacek, I., Zavadova, E., and Mohr, T.
Cytokine synthesis in human peripheral blood mononuclear cells
after oral administration of polyenzyme preparations
Desser L., Rehberger A., Kokron E., Paukovits W.
Concentrations of soluble tumor necrosis factor
receptors, b2-microglobulin, IL-6 and TNF in serum of multiple myeloma patients after
chemotherapy and after combined enzyme-therapy
Desser L., Sakalova A., Zavadova E., Holomanova D., Mohr T.
Systemic enzyme therapy in experimental atherosclerosis
Dosenko V.E., Zaharova V.P., Byts Y.V.
Effects of Oral Enzymes in Collagen II Induced
Arthritis in Mice
Emancipator S.N., Chintalacharuvu S.R., Urankar Nagy N., Petersilge C., Stauder, G.
Oral Enzymes in Different Animal Models of
Glomerulonephritis
Emancipator S.N., Chintalacharuvu S.R., Urankar Nagy N., Stauder G.
Enzyme therapy of experimental glomerulonephritis
Emancipator S.N., Lamm M.E.
Oral enzymes in different glomerulonephritis animal
models
Emancipator S.N., Nagy N.U., Chintalcharuvu S.R., Stauder G.
Therapy with proteolytic enzymes prolongs survival of
mouse heart allografts
Gaciong Z., Lasek W., Jakobisiak M., Stoklosa T., Paczek L., Heidland A.
Beneficial effect of proteases on allograft arteriosclerosis in a
rat aortic model
Gaciong Z., Paczek L., Bojakowski K., Socha K., Wisniewski M. and Heidland A.
Treatment with proteolytic enzymes inhibits vascular
allograft rejection in rats
Gaciong Z., Paczek L., Bojakowski K., Wisniewski M., Lao M., Heidland A.
Bromelain proteinase F9 augments human lymphocyte-mediated growth
inhibition of various tumor cells in vitro
Garbin F., Harrach T., Eckert K. and Maurer H. R.
Proteolytic Enzymes Modulate the Adhesion Molecule
CD44 on Malignant Cells in Vitro
Gebauer F., Micheel B., Stauder G., Ransberger K., Kunze R.
Enzymolysis of glomerular immune deposits in vivo with
dextranase-protease ameliorates proteinuria, hematuria, and mesangial proliferation in
murine experimental IgA nephropathy
Gesualdo L., Ricanati S., Hassan M.O., Emancipator S.N., Lamm M.E.
Bromelain proteases suppress growth, invasion and lung
metastasis of B16F10 mouse melanoma cells
Grabowska E., Eckert K., Fichtner I., Schultze-Forster K., Maurer H.R.
Bromelain treatment of human T cells removes CD44, CD45RA,
E2-MIC2, CD6, CD7, CD8, and Leu 8-LAM1 surface molecules and markedly enhances
CD2-mediated T cell activation
Hale L.P., Haynes B.F.
Bromelain proteinases modulate the CD44 expression on human
Molt 4-8 leukemia and SK-Mel 28 melanoma cells in vitro
Harrach T., Gebauer F., Eckert K., Kunze R., Maurer H.-R.
Malignant nephrosclerosis in Goldblatt hypertensive rats-
amelioration by systemic enzyme therapy
Heidland A., Sebekova K., Dämmrich J., Paczek L., Fierlbeck W., Krivosikova Z., Gaciong
Z.
Renal fibrosis- Role of Impaired protein degradation
and potential therapeutic strategies
Heidland A., Sebekova K., Paczek L., Teschner M., Daemmrich J., Gaciong Z.
Immunomodulation by a2-macroglobulin and
a2-macroglobulin-proteinase complexes- the effect on the human T lymphocyte response
Heumann D., Vischer T.L.
Low-dose chymotrypsin treatment inhibits neutrophil
migration into sites of inflammation in vivo- effects on Mac-1 and MEL-14 adhesion protein
expression and function
Jutila M.A., Kishimoto T.K., Finken M.
Comparison of media conditions to expand TIL-derived T-cell lines
from patients with peritoneal carcinomatosis including serum free, rIFN-g and polyenzyme
preparation
Kim Y.M, Zavadova E., Loercher A., Freedman R.S.
Effect of complex enzyme preparations on the
fibrinogen-fibrin system
Kizim A.I.
Selective modulation of cell adhesion molecules on lymphocytes by
bromelain protease 5
Kleef R., Delohery T.M., Bovbjerg D.H.
Mechanism of therapeutic efficacy of Wobenzym in the
treatment of toxic hepatitis
Korpan M.I., Korpan N.N., Tschekman I.S., Fialka V.
Pharmacological effect of Wobenzym on the blood
coagulation system
Korpan M.I., Korpan N.N., Tschekman I.S., Fialka V.
Estimation of efficacy of basic therapy of rheumatoid arthritis on the basis of systemic enzyme therapy- results of five-year monitoring
Kovalenko
V.N.,1 Shuba N.M.,2 Golovatskiy I.V.,1
Bortkevich O.P.,1 Yasinskaya V.A.2
Beta amyloid protein and plant cysteine proteinases influence the (3H)hemicholinium-3 binding site in vitro in rat hippocampus
Krištofiková Z., Klaschka J.
Evaluation of perspective agents for Alzheimer disease
therapy by means of in vitro test with beta amyloid protein
Krištofiková Z., Klaschka J., Majer E., Fales E.
Plant cysteine proteases - new supportive agents in Alzheimer disease therapy?
Kristofikova Z., Stastny F.
Amyloid beta peptide 1-40 influences a recognition site of hemicholinium-3 sensitive choline carriers and their proteolytic degradation
Krištofiková Z., Tejkalová H.
Amyloid Beta Peptide 1-40 and the Function of Rat Hippocampal Hemicholinium-3 Sensitive Choline Carriers- Effects of a Proteolytic Degradation In Vitro
Krištofiková Z., Tejkalová H., Klaschka J.
Proteolytic enzymes modulate the C 1 q-binding capacity
of fixed immunocomplexes in vitro
Kunze R., Ransberger K., Stauder G., Gebauer F.
Administration of proteolytic enzymes bromelain and trypsin diminish the number of CD4+ cells and the interferon-g response in Peyer’s patches and spleen in endotoxemic balb-c mice
Manhart N., Akomeah R., Bergmeister H., Spittler A., Ploner M., Roth E.
Modulation of human tumor associated macrophages from
malignant effusions with cytokines and proteolytic enzymes
Mohr T., Závadová E., Hauptmann E., Maca S., Neumann M., Salzer H., Micksche M.
Proteolytic enzyme treatment reduces glomerular immune
deposits and proteinuria in passive Heymann nephritis
Nakazawa M., Emancipator S.N., Lamm M.E.
Proteinases reduce metastatic dissemination and increase
survival time in C57Bl6 mice with the Lewis lung carcinoma
Olejár T, Wald M., Poucková P., Zadinová M.
Enteral administration of proteinase mixture delays and-or Inhibits inflammation development in irradiated rat lungs
Österreicher
J., Škopek J., Navrátil L., Knížek J., Šebková V., Macela A.
Enteral administration of proteinase mixture inhibits development of radiation pneumonitis and lung fibrosis in rats
Österreicher
J., Škopek J., Navrátil L., Knížek J., Šebková V., Macela A.
Beneficial effect of proteases on TGF-beta production
in glomeruli from streptozotocin induced diabetes mellitus in rats
Paczek L., Gaciong Z., Bartlomiejczyk I., Czyzyk A., Heidland A.
Protease administration decreases enhanced transforming growth factor-b1 content in isolated glomeruli of diabetic rats
Paczek L., Gaciong Z.,
Bartlomiejczyk I., Sebekova K., Birkenmeier G., Heidland A.
Systemic administration of papain enhances proteolytic activity in some regions of excitotoxin-damaged rat brain
Pliss L., Lisy V., Kristofikova Z., Stastny F.
Modulation of
autoimmunity to beta-cell antigens by proteases
Roep B.O., Van den Engel N.K., Halteren A.G.S., Duinkerken G., Martin S.
Enzyme and combination
therapy with cyclosporin A in the rat developing adjuvant arthritis
Rovenská E., Švík K., Stančíková M.,
Rovenský J.
Reduced phorbol-myristate-acetate activation of lymphocytes coincubated in vitro with trypsin
van
Schaik W.
Effect of Chronic Therapy with Proteolytic Enzymes on
Hypertension-Induced Renal Injury in the Rat Model of Goldblatt Hypertension
Šebeková K., Dämmrich J., Fierlbeck W., Krivosiková Z., Paczek L., Heidland
A.
Systemic Ttreatment with Proteolytic Enzymes in Rat
Models of Nonimmune Mediated Renal Diseases
Sebekova K., Dammrich J., Fierlbeck W., Krivosikova Z., Paczek L., Heidland A.
The effect of oral
protease administration in the rat remnant kidney model
Šebeková Katarína, Dämmrich Jobst, Krivošíková Zora, Heidland August
Amelioration of the progressive course of chronic
renal failure in subtotally nephrectomized rats by intraperitoneal enzyme therapy
Sebekova K., Daemmrich J., Paczek L., Gaciong Z., Blazicek P., Spustova V., Heidland
A.
Proteolytic enzymes in attenuation of tubulointerstitial fibrosis in various models of non-immune mediated renal disease
Šebeková K., Fierlbeck W., Krivošíková Z., Schinzel R., Dämmrich J.,
Galbavý Š., Blažíček P., Syrová D., Heidland A.
The effect of intraperitoneal administration of
Phlogenzym on the development of accelerated glomerulosclerosis in Goldblatt hypertensive
rats - MU-697 411
Sebekova K., Heidland A.
The effect of intraperitoneal administration of Phlogenzym
on the development of accelerated glomerulosclerosis in Goldblatt hypertensive rats
(MU-697411)
Šebeková K., Heidland A., Krivošíková Z., Daemmrich J.
Amelioration of the development of chronic renal failure
by systemic enzyme treatment in the rat model of 5-6 nephrectomy
Sebekova K., Paczek L., Dämmrich J., Ling H., Schenk O., Gaciong Z., Spustova V.,
Heidland A.
Effects of protease therapy in the remnant kidney model
of progressive renal failure
Sebekova K., Paczek L., Dämmrich J., Ling H., Spustova V., Gaciong Z., Heidland A.
Phlogenzym may prevent metabolic injuries to myocardium. Results of a laboratory experiment with rats
Skutelis A., Pule E., Purvins I.,
Baltkajs J., Skromanis M., Zeibarts M.,
Desser L., Österreicher J., Ansbergs J.
Reduction of cisplatin-induced nephrotoxicity by proteolytic enzymes in tumor-bearing rats
Solyanik G.I., Todor I.N., Yurchenko O.V.,
Ponomareva O.V., Banakhevych N.V., Terzov A.I., Chekhun V.F.
Oral enzyme therapy in the animal model of collagen-II
induced arthritis in mice
Stauder G.
The effect of enzyme therapy and natrium alendronan on ovariectomized female rats
Svik K., Rovenska E., Stancikova M., Rovensky J.
Interaction Between Proteases and Blood-Brain
Barrier- Possible Sequellae for Clinical Praxis
Šťastny
F., Pliss L., Höschl C.
Effect of enzyme therapy and combination therapy with alendronate on the ovariectomized
rats.
Švík
K., Rovenská E., Stančíková M., Ištok R., Rovenský J., Veselková Z.
The role of CD44 in tumor growth and metastasis
Sy Man-Sun
Potential of Targeting Cell Surface CD44 Proteins with
Proteinases in Preventing Tumor Growth and Metastasis
Sy M.S., Liu D., Kogerman P., Culp L.A.
Prevention of Murine EAE by Oral Hydrolytic Enzyme
Treatment
Targoni O.S., Tary-Lehmann M., Lehmann P.V.
Complex formation of physiologically active
components of Wobe-Mugos with biomembrane components
Tschekman I.S., Bobkov V.N., Zagorodnyi M.I.
Biochemical mechanisms of therapeutic effect of
complex enzyme preparations
Veremeenko K.N.
The influence of human blood plasma inhibitors on the activity of serine and cysteine proteinases
Veremeenko K.N., Kizim A.I., Terzov A.I., Dosenko V.E., Nosenko O.A.
Effect of proteinase mixture on the growth of breast cancer in the experiment
Wald M., Olejár T., Poučková P., Zadinová M.
Proteinases Reduce Metastatic Dissemination and Increase
Survival Time in C57Bl6 Mice with the Lewis Lung Carcinoma
Wald M., Olejár T., Poučková P., Zadinová M.
The influence of proteinases on in vivo blastic
transformation in rat species SD-Ipcv with spontaneous lymphoblastic leukemia
Wald M., Olejár T., Poučková P., Zadinová M.
Therapeutic effect of enzyme mixture of trypsin,
chymotrypsin and papain (Wobe-Mugos ) in rats SD-Ipcv with spontaneous lymphoblastic
leukemia
Wald M., Olejár T., Poučková P., Zadinová M.
The influence of trypsin, chymotrypsin and papain on the
growth of human pancreatic adenocarcinoma transplanted to nu-nu mice
Wald M., Poučková P., Hloušková D., Altnerová M.,
Olejár T.
The effect of rectally administered proteinases in
animal models of malignancies
Wald M., Poučková P., Zadinová M., Olejár T.
Proteolytic enzymes prevent B16 melanoma metastasizing in
C57Bl6 mice
Wald M., Ransberger K., Poučková P., Zadinová M.,
Boubelík M., Olejár T.
Proteinase administration reduces growth of human breast and pancreatic cancer in nude mice and diminishes expression of some tumorigenesis biomarkers
Wald M., Šebková
V., Österreicher J., Zadinová M., Poučková P.
Polyenzyme Preparation WOBE-MUGOS® Inhibits Growth of
Solid Tumors and Development of Experimental Metastases in Mice
Wald M., Závadová E., Poucková P., Zadinová M., Boubelík M
Adhesion Molecule Modulation- Downregulation of Vitronectin Receptor Expression by Cytokines and a Polyenzyme Preparation in Human Melanoma Cell Lines
Wenning G., Desser L., Zavadova E., Wrba H.
Targeted enzyme therapy of experimental
glomerulonephritis in rats
White R.B., Lowrie L., Stork J.E., Iskandar S.S., Lamm M.E., Emancipator S.N.
Protease Treatment Delays Diabetes Onset in
Diabetes-prone Nonobese Diabetic (NOD) Mice
Wiest-Ladenburger U., Richter W., Moeller P., Boehm B. O.
Effects of single compounds used in oral enzyme
therapy in different in vitro and in vivo models of inflammation
Wood G.R., Ziska T., Morgenstern E., Stauder G.
Sequential effects of an oral enzyme combination
with rutosid in different in vitro and in vivo models of inflammation
Wood G.R., Ziska T., Morgenstern E., Stauder G.
Advanced glycation end products (AGEs)-induced expression of TGF-b1 is suppressed by a protease in the tubule cell line LLC-PK1
Xiang G., Schinzel R., Simm A., Münch G., Sebekova
K., Kasper M., Niwa T., Schmitz Ch. and Heidland A.
Advanced glycation end products impair protein turnover in LLC-PK1- Amelioration by trypsin
Xiang G., Schinzel R., Simm A., Sebekova K., Heidland A.
Oral treatment with polyenzyme preparations stimulates
cytotoxicity in human polymorphonuclear leukocytes
Zavadova E., Desser L.
Proteolytic enzymes stimulate the cytotoxic
activity of human granulocytes in vitro and in vivo
Zavadova E., Desser L.
Stimulation of reactive oxygen species production and
cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme
preparation
Zavadova E., Desser L., Mohr T.
Maturation of dendritic cells (D.C.) from ovarian cancer
patients
Závadová E., Savary C., Freedman R.S.
Maturation of dendritic cells from ovarian cancer patients
Zavadova E., Savary C. A., Templin S.,
Verschraegen C. F., Freedman R. S.
Materials available only in Russian 