Contents - Oncology brit.jpg (17257 bytes)


Breast lymphedema after partial mastectomy. A complication of conservative surgical methods
Adámek J., Prausová J., Wald M.

Reduction of radiation side-effects by hydrolytic enzymes
Beaufort F.

Efficacy and safety of adjuvant treatment with Wobe-Mugos E in breast cancer
Beuth J.,  Bock P.R.,  Hanisch J.

Impact of complementary oral enzyme application on the postoperative treatment results of breast cancer patients - results of an epidemiological multicentre retrolective cohort study
Beuth J., Ost B., Pakdaman A., Rethfeldt E., Bock P. R., Hanisch J., Schneider B.

Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix- evidence of the reduction of acute side effects
Dale P.S., Tamhankar C.P., George D., Daftary G.V.

Polyenzyme preparations interrupt the autocrine loop of TGFb production in melanoma cells by conversing a2Macroglobulin (a2M) in to the fast-form which binds TGF-beta irreversible 
Desser, L., Herbacek, I., Zavadova, E., and Mohr, T.

Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations
Desser L., Rehberger A., Kokron E., Paukovits W.

Concentrations of soluble tumor necrosis factor receptors, b2-microglobulin, IL-6 and TNF in serum of multiple myeloma patients after chemotherapy and after combined enzyme-therapy
Desser L., Sakalova A., Zavadova E., Holomanova D., Mohr T.

Oral enzyme therapy improves remission time, soluble TNF-receptors and b2-microglobulin concentration in chemotherapy treated multiple myeloma patients
Desser L., Sakalova A., Zavadova E., Holomanova D., Mohr T.

Oral enzymes as additive cancer therapy
Desser L., Zavadova E., Herbacek I.

Kaposi's sarcoma and lymphedema - report of 2 cases
Džupina A., Džupina M., Morvay P.

Proteolytic enzymes in lymphedema therapy
Dzupina A., Morvay P., Dzupina M.

Proteolytic enzymes in lymphedema therapy
Džupina A., Morvay P., Džupinová M., Miškaninová A.

Bromelain proteinase F9 augments human lymphocyte-mediated growth inhibition of various tumor cells in vitro
Garbin F., Harrach T., Eckert K. and Maurer H. R.

Proteolytic Enzymes Modulate the Adhesion Molecule CD44 on Malignant Cells in Vitro
Gebauer F., Micheel B., Stauder G., Ransberger K., Kunze R.

Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells
Grabowska E., Eckert K., Fichtner I., Schultze-Forster K., Maurer H.R.

Enzymes in the treatment of patients with malignant lymphoma presenting with large tumor mass
Gubareva A.A.

Oral enzymes preventing side effects of radiation therapy in patients with head and neck cancers
Gujral M.S., Patnaik P.M., Kaul R., Daftary G.V., Parikh H.K., Tamhankar C.P., Schiess W.

Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers
Gujral M.S., Patnaik P.M., Kaul R., Parikh H.K., Conradt C., Tamhankar C.P., Daftary G.V.

Bromelain proteinases modulate the CD44 expression on human Molt 4-8 leukemia and SK-Mel 28 melanoma cells in vitro
Harrach T., Gebauer F., Eckert K., Kunze R., Maurer H.-R.

Long-term follow-up of larynx leukoplakia under treatment with retinyl palmitate
Issing W.J., Struck R., Naumann A.

Systemic enzyme therapy
Jezdinsky J.

Lymphedema
Kafková H., Kojanová M.

Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer
Kasseroller R., Wenning H.G.  

Comparison of media conditions to expand TIL-derived T-cell lines from patients with peritoneal carcinomatosis including serum free, rIFN-g and polyenzyme preparation
Kim Y.M, Zavadova E., Loercher A., Freedman R.S.

Introduction to Oral Enzyme Therapy
Kleine M.-W.

Enzyme therapy in patients with advanced colorectal cancer
Klek S., Popiela T., Kulig J., Wachol D., Bock P.R., Hanish J., Stauder G.

Effectiveness of the polyenzymic drug preparation WOBE-MUGOS E in lymphoproliferative diseases
Kolomoets M.Yu., Antofiychuk M.P.

Systemic enzyme therapy in oncology
Leipner J., Saller R.

Initial experience in the treatment of oral leukoplakia with high-dose vitamin A and follow-up 5-aminolevulinic acid induced protoporphyrin IX fluorescence
Leunig A., Betz Ch. S., Baumgartner R., Grevers G., Issing W.J.

Systemic enzyme therapy in prevention of postirradiation complications
Lukáš J., Betka J., Klozar J., Taudy M., Honzíková M.

Proteolytic enzymes in prevention and treatment of lymphatic oedema of arm after axillary dissection or radiotherapy
Macháňová M., Wald M., Bechyně M., Prausová J., Adámek J.

Proteases - drug of the choice in the pharmacotherapy of lymphedema
Machanova M., Wald M., Prausova. J., Bechyne M., Adamek J.

Bromelain proteases as immunomodulators for therapy of mammary tumors
Maurer H.R.

Modulation of human tumor associated macrophages from malignant effusions with cytokines and proteolytic enzymes
Mohr T., Závadová E., Hauptmann E., Maca S., Neumann M., Salzer H., Micksche M.

Systemic enzymotherapy in recurrent laryngeal papillomatosis - our five year's experience
Mudrák J., Koval J., Bobák L.

Does adjuvant enzymotherapy influence recurrence of Schneiderian papillomas?
Mudrák J., Sokol L., Andrašovská M., Koval J.

Lymphoedema and its therapeutic options
Navrátilová Z.

Proteinases reduce metastatic dissemination and increase survival time in C57Bl6 mice with the Lewis lung carcinoma
Olejár T, Wald M., Poucková P., Zadinová M.

The effect of systemic enzyme therapy (Phlogenzym) in the treatment of radiomucositis in patients with laryngeal cancer
Pluzhnikov M.S., Ryabova M.A., Karpiscenko S.A.

Enzyme therapy in patients with advanced colorectal cancer
Popiela T.1, Kulig J.1, Klek S.1, Wachol D., Bock P.R.2, Hanish J.2

Influence of an additional treatment with oral enzymes on patients with colorectal cancers
Popiela T., Kulig, Bock P.R., Hanisch J.

Influence of a complementary treatment with oral enzymes on patients with colorectal cancers – an epidemiological retrolective cohort study
Popiela T., Kulig J., Hanisch  J., Bock P. R.

Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer
Popiela T., Kulig J., Klek S., Wachol D.J., Bock P.R., Hanisch J.

Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer
Popiela T., Kulig J., Klek S., Wachol D.J., Bock P.R., Hanisch J.

Systemic enzyme therapy as a supportive treatment in oncology
Prausová J., Adámek J., Wald M.

Enzyme therapy as pre- and postsurgical adjuvans in the treatment of breast cancer
v. Rokitansky O., Stauder G., Streichhan P.

Retrolective cohort study of an additive therapy with an oral enzyme preparation in patients with multiple myeloma
Sakalová A., Bock P.R., Dedík L., Hanisch J., Schiess W., Gažová S., Chabroňová I., Holomanová D., Mistrík M., Hrubiško M.  

Survival analysis of an additional therapy with oral enzymes in patients with multiple myeloma
Sakalová A., Dedík L., Bock P.R., Hanisch J., Schiess W.

Recent immunological approaches and therapy of multiple myeloma
Sakalová, A., Desser, L., Bucová, M., Stauder. G. , Ransberger, K.

Enzyme therapy improved remission time, soluble TNF-receptors and b2-microglobulin concentration in chemotherapy treated multiple myeloma patients
Sakalova A., Desser L., Zavadova E., Holomanova E., Mohr T.

Progression markers in serum of patients with multiple myeloma
Sakalová A., Herbacek I., Desser L., Holomáňová D., Mohr T.

The problem of osteoporosis in multiple myelomas
Sakalová A., Herrmann Z., Gažová S., Chabroňová I., Dedík L., Mistrík M., Hrubiško M.

Reduction of osteoporotic pathologic fractures and survival prolongation after long-term administration of biophosphonates in multiple myeloma
Sakalová A., Herrmann Z., Mistrík M., Hrubiško M., Gažová S., Chabroňová I., Dedík L.

Diagnosis and therapy of systemic amyloidosis
Sakalová A., Rovenský J., Škultétyová D., Škultéty J., Mistrík M., Šteruská M., Hrubiško M.

The differential diagnosis and treatment of Waldenström macroglobulinaemy
Sakalová A., Škultéty J., Škultétyová D., Mistrík M., Gažová S., Chabroňová I.

Adjuvant therapy with hydrolytic enzymes in oncology - a hopeful effort to avoid bleomycinum induced pneumotoxicity
Schedler M., Lind A., Schätzle W., Stauder G.

Preliminary results of the combined treatment for patients with lung cancer and malignant thymomas using Wobe-Mugos
Smolanka I.I., Ganul V.L.

Enzyme Therapy of Patients with Acute Hemorrhagic Cystitis
Sökeland J.

Radiotherapy side-effects in abdominal cancer patients and their reduction by hydrolytic enzyme preparations
Stauder G., Beaufort F., Streichhan P.

The role of CD44 in tumor growth and metastasis
Sy Man-Sun

Potential of Targeting Cell Surface CD44 Proteins with Proteinases in Preventing Tumor Growth and Metastasis
Sy M.S., Liu D., Kogerman P., Culp L.A.

Systemic amyloidosis in incipient plasmocytoma
Szántová M., Kupčová V., Sakalová A.

Incidental plasmocytoma
Szántová M., Sakalová A, Gažová S, Kupčová V.,

Systemic enzyme therapy in complex treatment of patients with breast cancer
Tarutinov V.I., Galakhin K.A., Ros N.V., Shpyleva S.I.

Systemic enzyme therapy in the complex treatment of breast cancer
Tarutinov V.I., Nosa P.P., Ros N.V., Galakhin K.A., Shpilevaja S.I.

Administration of Wobenzym in the complex therapy of patients suffering from ORL cancer
Ušakov V.S.

Systemic enzyme therapy, basic theoretical aspects, clinical application experience.
Veremeenko K.N., Kovalenko V.N.

Diagnosis and treatment of lymphedema
Wald M.

Non-extremity lymphedema following axilla dissection and radiotherapy
Wald M., Eliška O., Křížová H.

Diagnosis of an early (latent) stage of secondary lymphedema of the arm - a necessary condition for its successful treatment
Wald M., Křížová H.

Proteases in a medicamentous treatment of lymphedema
Wald M., Křížová H., Prausová J., Adámek J.

Secondary lymphoedema after lymphadenectomies
Wald M., Křížová H., Prausová J., Adámek J.

Proteinases Reduce Metastatic Dissemination and Increase Survival Time in C57Bl6 Mice with the Lewis Lung Carcinoma
Wald M., Olejár T., Poučková P., Zadinová M.

The influence of proteinases on in vivo blastic transformation in rat species SD-Ipcv with spontaneous lymphoblastic leukemia
Wald M., Olejár T., Poučková P., Zadinová M.

Therapeutic effect of enzyme mixture of trypsin, chymotrypsin and papain (Wobe-Mugos ) in rats SD-Ipcv with spontaneous lymphoblastic leukemia
Wald M., Olejár T., Poučková P., Zadinová M.

Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16
Wald M., Olejár T., Šebková V., Zadinová M., Boubelík M., Poučková P.

The influence of trypsin, chymotrypsin and papain on the growth of human pancreatic adenocarcinoma transplanted to nu-nu mice
Wald M., Poučková P., Hloušková D., Altnerová M., Olejár T.

The effect of rectally administered proteinases in animal models of malignancies
Wald M., Poučková P., Zadinová M., Olejár T.

Proteolytic enzymes prevent B16 melanoma metastasizing in C57Bl6 mice
Wald M., Ransberger K., Poučková P., Zadinová M., Boubelík M., Olejár T.

Polyenzyme Preparation WOBE-MUGOS® Inhibits Growth of Solid Tumors and Development of Experimental Metastases in Mice
Wald M., Závadová E., Poucková P., Zadinová M., Boubelík M.

Adhesion Molecule Modulation- Downregulation of Vitronectin Receptor Expression by Cytokines and a Polyenzyme Preparation in Human Melanoma Cell Lines
Wenning G., Desser L., Zavadova E., Wrba H.

Systemic Enzyme Therapy - Newest Status and Progress
Wrba H.

Chemoprevention of cancer for the next millennium - quo vadis?
Zänker K.S.

Oral treatment with polyenzyme preparations stimulates cytotoxicity in human polymorphonuclear leukocytes
Zavadova E., Desser L.

Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation
Zavadova E., Desser L., Mohr T.

The role of macrophages in antitumor defense of patients with ovarian cancer
Zavadova E., Loercher A., Verstovsek S., Verschraegen Claire F.,  Micksche M., and Freedman Ralph S.

Maturation of dendritic cells (D.C.) from ovarian cancer patients
Závadová E., Savary C., Freedman R.S.

Maturation of dendritic cells from ovarian cancer patients
Zavadova E., Savary C. A., Templin S., Verschraegen C. F., Freedman R. S.

FDA grants orphan drug status to Wobe-Mugos for multiple myeloma


Inhalt - Onkologie german.jpg (1657 bytes)


Einsatz von WOBE-MUGOS® zur Reduzierung von Strahlennebenwirkungen nach Radiatio im Abdominalbereich (MU-87105)
Beaufort F.

Reduzierung von Strahlennebenwirkungen durch hydrolytische Enzyme
Beaufort F.

Einfluß von Enzympräparaten auf Gerinnung und Metastasierung maligner Tumoren
Drevs J., Unger C.

Proteolytische Enzyme in der Lymphoedemtherapie
Džupina A., Morvay P., Džupinová M., Miškaninová A.

Wobe-Mugos® als adjuvante Therapie bei Patienten unter Chemo- oder Strahlentherapie
Heinz R.

Wobenzym® - und Diuretikatherapie beim Lymphödem nach Mammaoperation
Korpan M.I., Fialka V.

Bromelain in der komplementären Tumortherapie
Maurer H.R. und K. Eckert

Zur Enzymtherapie entzündlicher Venenerkrankungen, der tiefen Beinvenenthrombose und des postthrombotischen Syndroms
Mehr H.

15 Jahre operative Behandlung des Mammakarzinoms mit adjuvanter Enzymtherapie
Rokitansky O.

Enzymtherapie als prä- und postoperatives Adjuvans bei der Brustkrebsbehandlung
v. Rokitansky O., Stauder G., Streichhan P.

Die Bedeutung der Enzymtherapie bei der Krebsbehandlung
Scheef W.

Strahlentherapeutische Nebenwirkungen bei Abdominal-krebspatienten und deren Reduktion durch hydrolytische Enzympräparate
Stauder G., Beaufort F., Streichhan P.

Die Therapie der radiogenen Mukositis mit Enzymen
Vinzenz K., Stauder U.

Additive Tumortherapie mit proteolytischen Enzymen
Wrba H.

Systemische Enzymtherapie - Aktueller Stand und Fortschritte
Wrba H.

Klinische Interventions - studien zur Chemoprävention
Zänker K.S.

Kompendium Internistische Onkologie. Standards in Diagnostik und Therapie
Zänker K.S.

Modulierung des Immunsystem mit Enzympräparaten unterstütz die Standardtherapie


Materials available only in Russian   russia.jpg (3828 bytes)


Systemic enzyme therapy (Phlogenzym) in the treatment of radiomucositis in patients with laryngeal cancer
Pluznikov M.S., Riabova M.A., Karpischenko S.A.