What is the Mechanism of „Immunonormalizing“ Effects of Proteolytic Enzyme Combination
in the Systemic Enzyme Therapy?

Ferencik M.

Imunologický ústav lekárskej fakulty UK a Neuroimunologický ústav SAV, Bratislava

Alergie 2003, 1, pp. 59 – 62

Czech abstract

Summary
Combinations of proteolytic enzymes orally administered in the systemic enzyme therapy may have some immunomodulatory effects. On principle, they may operate beneficially in the prevention and/or combinated therapy of some diseases especially with the inflammatory etiology. At the present, the presumed immunonormalizing effects of these preparations are not sufficiently demonstrated yet. The possibility of more precise administration of the enzyme preparations in different diseases treatment would be certainly improved after better explanation of their mechanism of action on the molecular and cellular level as well as with the greater number of controlled clinical studies.
Key words: systemic enzyme therapy, immunonormalization, defensive and damaging inflammation, protease-activated receptors (PARs), Toll-like receptors (TLRs)